ABSTRACT
Curcumin is widely known for its antibacterial, antioxidant and anti inflammatory effects and has been reported to possess anticancerous activity as well. However, its medical application is limited because of poor bioavailability and rapid metabolism. In this study, we encapsulated curcumin in solid lipid nanoparticles and studied its anticancerous effect in Dalton’s Ascites Lymphoma (DAL) mice model. The physicochemical characteristics of curcumin solid lipid nanoparticles (CUR-SLN) were assessed and the anticancer efficacy was determined by in vivo studies. The curcumin solid lipid nanoparticles were synthesized by solvent emulsification evaporation method with particle size less than 100 nm. Antitumor effect of nanocurcumin (50 mg/kg) and curcumin (100 mg/kg) was evaluated in Dalton’s Ascites Lymphoma bearing mice. Pathological and immunohistochemical parameters were studied. Mean survival time and percentage increase in lifespan were assessed. Nanocurcumin group showed more significant influence in reducing tumor volume and weight, inducing apoptosis, reducing angiogenesis and invasion restoring antioxidant parameters and increased mean survival time. Curcumin and nanocurcumin inhibited the activation of nuclear factor-kappa B (Nf-kB), and thereby proved the pathway by which it induced anti-angiogenic and anti-invasive property.
ABSTRACT
Background: Iron deficiency is responsible for most of the nutritional anemia. Hemoglobin concentration is a reliable indicator of anemia at the population level, as opposed to clinical measures which are subjective and therefore have more room for error. Measuring Hemoglobin concentration is relatively easy and inexpensive, and this measurement is frequently used as a proxy indicator of iron deficiency. To study the association of certain risk factors with the prevalence of anemia in school children in the age group of 8-14 years.Methods: The study was conducted from April 2017 to March 2018 in Department of Paediatrics, Government Thiruvarur Medical College, Thiruvarur. The study population consisted of school children in the age group of 8 to 14 years fulfilling the inclusion and exclusion criteria. The sample size was 250. Complete hematological investigations was done to each child for differential diagnosis of anemia.Results: Majority of the children studied had a normal BMI 38.4% (n=96), 16.8% (n=42) were classified as overweight, 9.2% (n=23) were classified as obese. 22.8% (n=57) were classified as having thinness. 12.8% (n=32) were classified as having severe thinness. Of the 132 children with anemia, majority had mild anemia 64.39% (n=85) followed by moderate 28.03% (n=37) and severe anemia 7.58% (n=10). Of the 132 children with anemia, majority had mild anemia 64.39% (n=85) followed by moderate 28.03% (n=37) and severe anemia 7.58% (n=10).Conclusions: The prevalence of anemia was significantly higher in female children (64.91%) compared to male children (42.65%). The prevalence of anemia is highest in children with severe thinness (78.13%) followed by children with obesity (73.91%). The most common type of anemia in our study was iron deficiency anemia. Majority of the children were suffering from anemia of mild severity. There was no statistically significant correlation between the prevalence of anemia in children and age and socioeconomic status.
ABSTRACT
The physical, chemical and total heterotrophic bacteriological parameters (THBP) bacterial population were measured at three sampling stations namely Upper Anicut (S1), Chinthamani road bridge (S2) and Grand Anicut (S3) for a period of three month January to March 2007 in the river Kaveri, Tiruchirappalli. The pH ranged from 6.7 to 7.8, the level of solids and total hardness was high in station S2 when compared to other stations. Station 2 registered a minimum level of DO (3.6 mg l(-1)), and the BOD and COD varied from 3.47 to 4.27, 20.67 to 41.47 mg l(-1) respectively. THBP colony count was found to be high in S2 (8.16 x 10(2) CFU ml(-1)) and a lowest level in S1 (2.64 x 10(2)) and S3 (1.80 x 10(2)). It was observed in the present study that in reservoir (anicut) stations factors like pH, TDS, TSS, Hardness and THBP were at lower level than for the water at Chinthamani road bridge (S2), probably due to the mixing of municipal sewage at this point.
Subject(s)
Environmental Monitoring , Hydrogen-Ion Concentration , India , Rivers/chemistry , Water Pollutants/analysisABSTRACT
Diversity of Pink-Pigmented Facultative Methylotrophs (PPFMs) in phyllosphere of cotton, maize and sunflower was determined based on differential carbon-substrate utilization profile and Random Amplified Polymorphic DNA data. Results indicate that six diversified groups of PPFMs are found in these crops. Sunflower and maize phyllosphere harbor four different groups of methylobacteria while cotton has only two groups.
A diversidade de microrganismos metilotróficos facultativos pigmentados (PPFMs) na filosfera de algodão, milho e girassol foi determinada baseada no perfil diferencial de utilização de substratos de carbono e em dados de RAPD. Os resultados indicaram a existência de seis grupos diferentes de PPFMs nessas plantas. As filosferas de girassol e milho apresentaram quatro grupos diferentes de metilobactérias enquanto a de algodão apresentou apenas dois grupos.